Immunogenic composition for MERS coronavirus infection

Patent No: US 9889194B2 Immunogenic composition for MERS coronavirus Infection

Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.

Coronaviruses infect and cause disease in a wide variety of species, including bats, birds, cats, dogs, pigs, mice horses, whales, and humans. Bats act as a natural reservoir for coronaviruses. Most infections caused by human coronaviruses are relatively mild. However, the outbreak of severe acute respiratory syndrome ( SARS ) caused by SARC - CoV in 2002 - 2003, and fatal infection in 2012 caused by a recently identified coronavirus, Middle East respiratory syndrome coronavirus ( MERS - CoV , also known as hCoV - EMC or NCOV ) demonstrated that coronaviruses are also able to cause severe , sometimes fatal disease in humans.